English
norskBlar i forfatter "Sovershaeva, Evgeniya"
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Composition of gut microbiota of children and adolescents with perinatal HIV infection taking antiretroviral therapy in Zimbabwe
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-24)<p><i>Background - </i>Human immunodeficiency virus (HIV) infection causes impairment of the gastrointestinal barrier, with substantial depletion of CD4<sup>+</sup> T cells in the gut. Antiretroviral therapy (ART) restores CD4<sup>+</sup> counts and may have beneficial effects on gut microbiota in adults. Little is known about effect of long-term ART on gut microbiome in HIV-infected children. We ... -
Cytomegalovirus-SpecificImmunoglobulin G is associated with chronic lung disease in children and adolescents from sub-Saharan Africa with perinatal HIV infection
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-26)In a cross-sectional study of 296 children and adolescents from Zimbabwe living with perinatal human immunodeficiency virus, individuals with the top tertile of cytomegalovirus-specific immunoglobulin G titer had an increased odds of chronic lung disease (odds ratio, 3.33; 95% confidence interval, 1.37–8.85; P = .010). -
“The effect of 48-weeks azithromycin therapy on levels of soluble biomarkers associated with HIV-associated chronic lung disease”
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-20)Objectives - HIV-associated immune activation contributes to chronic lung disease (CLD) in children and adolescents living with HIV. Azithromycin has immunomodulatory and anti-microbial properties that may be useful for treating HIV-associated CLD (HCLD). This study describes the effect of azithromycin on expression of plasma soluble biomarkers in children and adolescents with HCLD.<p> <p>Methods ... -
Exhaled nitric oxide is associated with inflammatory biomarkers and risk of acute respiratory exacerbations in children with HIV-associated chronic lung disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-07)Objectives: Chronic lung disease is a recognized complication in children with HIV. Acute respiratory exacerbations (ARE) are common among this group and cause significant morbidity. Exhaled nitric oxide (eNO) is a known marker of local airway inflammation. We investigated the association between eNO and ARE, biomarkers of systemic inflammation, and the effect of azithromycin on eNO levels.<p> ... -
High lactose whey cheese consumption and risk of colorectal cancer - The Norwegian Women and Cancer Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-22)The incidence of colorectal cancer (CRC) has increased among Norwegian women, and is among the highest in the world. In order to understand this increase, country specific dietary exposures have been investigated. The aim of this study was to quantify the association between consumption of brown cheese, a common bread topping in Norway, and colorectal, colon, and rectal cancer in the prospective ... -
History of tuberculosis is associated with lower exhaled nitric oxide levels in HIV-infected children
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-01)<p><i>Objective - </i>HIV disrupts host defense mechanisms and maintains chronic inflammation in the lung. Nitric oxide is a marker of lung inflammation and can be measured in the exhaled air. We investigated the relationship between exhaled nitric oxide (eNO), HIV status and airway abnormalities in perinatally HIV-infected children aged 6–19 years. <p><i>Design - </i>A cross-sectional study. <p ... -
HIV-infection in children and adolescents in Zimbabwe: viral suppression, airway abnormalities and gut microbiota.
(Doctoral thesis; Doktorgradsavhandling, 2019-12-10)Sub-Saharan Africa remains the region with the highest burden of HIV among both children and adults. Access to antiretroviral therapy (ART) has improved survival, yet data on long-term virological outcomes are scarce. In addition, recent evidence indicates that HIV-infected ART-treated children are at increased risk of lung impairment, and data on the pathological mechanisms involved are limited. ... -
Patterns of detectable viraemia among children and adults with HIV infection taking antiretroviral therapy in Zimbabwe
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-31)<i>Objective</i>: To investigate the incidence and predictors of viraemia among individuals on antiretroviral therapy (ART) in Harare, Zimbabwe.<p> <p><i>Methods</i>: Children (0–19 years) and adults (>19 years) starting ART between 2013 and 2015 were followed for a median of 2.8 and 2.7 years, respectively. The incidence rates of virological failure (VF), low-level viraemia (LLV), and viral ...
